Jobs

Employment type / Anstellungsverhältnis:  Temporary Workload percentage / Pensum:  100% Location / Standort:   Davos Platz, CH Experience level / gewünschtes Erfahrungsniveau:  Students / Interns Application language / Bewerbungssprache:  English or German Short Description   Fracture-related infection (FRI) remains one of the most challenging complications in orthopaedic trauma, frequently resulting in bone destruction, implant failure, and prolonged treatment. Recent evidence suggests that early infection-induced bone loss is primarily driven by neutrophil-mediated inflammation and proteolytic degradation, alongside classical osteoclast-driven pathways.  This project (DONUT – Development of advanced Osteolysis Model drive by NeUTrophils) aims to further our knowledge on this topic by developing a novel human-relevant 3D in vitro model that integrates: Spatially organized bone constructs generated using Sound-Induced Morphogenesis Integration of immune cell populations including neutrophils Controlled introduction of Staphylococcus aureus Advanced molecular and imaging-based readouts The project will enable mechanistic insights into infection-induced osteolysis and provide a platform for testing new therapeutic strategies.   Start of work: Position will remain open until role is filled, preferred start by October 2026. Duration: 4 years Main Responsibilities   Develop and optimise 3D biofabricated bone model with immune cells Establish infection models with Staphylococcus aureus Introduce and study neutrophil-driven inflammatory processes Apply advanced analytical techniques (e.g. imaging, transcriptomics, cytokine profiling) Analyse and interpret experimental data Contribute to scientific publications and presentations

Employment type / Anstellungsverhältnis:  Temporary Workload percentage / Pensum:  100% Location / Standort:   Davos Platz, CH Experience level / gewünschtes Erfahrungsniveau:  Students / Interns Application language / Bewerbungssprache:  English or German Short Description This PhD position is part of the PREPARE project (Programmable Release of Prophylactic Antibacterial & Response Enhancing agents), a collaborative initiative between the Infection Biology and Biomedical Materials Focus Areas at the AO Research Institute Davos and CK CARE (Prof. Pierre Yves Mantel).  The Ph.D. student will be formally affiliated with the University of Fribourg and will be co-supervised by Prof. Michael Walch, Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine at the University of Fribourg. Fracture-related infection (FRI) remains a major clinical challenge despite current prophylactic strategies. Increasing evidence shows that early infection establishment is driven by rapid formation of Staphylococcus aureus microaggregates and transient impairment of neutrophil antibacterial function following trauma. The PREPARE project aims to address this problem by: Defining the earliest events enabling bacterial survival in the surgical field (aggregate formation, fibrin encapsulation, antibiotic tolerance) Identifying small-molecule immunomodulators that enhance neutrophil antibacterial activity Contributing to the development of next-generation responsive biomaterials for localized infection prevention    Start of work: Position will remain open until role is filled, preferred start by October 2026.  Duration: 4 years  Main Responsibilities   Establish and optimise advanced 3D in vitro infection models (e.g. staphylococcal abscess communities) Investigate early events in infection establishment, including bacterial aggregation, fibrin encapsulation, and antibiotic tolerance Characterise neutrophil–bacteria interactions, including phagocytosis, ROS production, and bacterial killing Identify and evaluate immunomodulatory compounds that enhance neutrophil function Perform cell culture and co-culture experiments using primary human neutrophils and bacterial pathogens Apply advanced techniques including confocal microscopy, flow cytometry, and molecular assays Analyse and interpret complex experimental datasets Contribute to interdisciplinary collaboration with biomaterials researchers within the PREPARE project

Short Description   We are seeking a proactive and customer-focused IT Supporter to provide technical assistance and support to the AO employees. The successful candidate will be responsible for troubleshooting hardware and software issues, supporting end users, maintaining IT equipment, and ensuring the smooth operation of IT systems and services. Since the role is officialy based in the AO headquarters, a proximity living in Davos area is strongly desired. Main Responsibilities   Ensure first-level support for users via phone, email, and on-site for software and hardware issues. Install and set up hardware for end-users. Document and track all support requests in our ticketing system. Maintain and update user documentation and the knowledge base. Provide support for internal training courses and events. Collaborate on internal IT projects as needed. Support our offices in Davos, Zizers and Zurich.

Short Description   Purpose of the Role: This combined role covers both strategic information security leadership and operational IT security management. As Information Security Responsible (ISR), the position holder defines the security strategy, owns governance and risk oversight, and ensures compliance with agreed information security requirements at an executive level comparable to a CISO function. As IT Security Manager, the position holder translates this strategy into effective structures, processes, controls, and operational security practices in close collaboration with the Head of Infrastructure, Head of IT, the IT Management Team, and relevant stakeholders.   Reporting line: Direct report to Head of IT, line to CEO in case of conflicts of interest in relation to the role of Information Security Responsible   Place of work: Davos, 3 days per week in office Main Responsibilities   Strategic security leadership and governance: Define, align, and maintain the information security strategy, policies, standards, ISMS, and governance model in line with organizational objectives, regulatory requirements, and stakeholder expectations. Risk, compliance, and control oversight: Identify, assess, and manage information security risks; ensure agreed security controls are implemented, monitored, audited, and continuously improved. Security operations and incident management: Lead and coordinate cyber security operations, incident response, threat analysis, threat hunting, remediation activities, lessons learned, and operational security reporting. Security architecture and technical control management: Oversee secure configuration, hardening, patch management, monitoring, and security architecture in collaboration with IT leadership, infrastructure, enterprise architecture, and operational IT teams. Business continuity, crisis, and stakeholder communication: Contribute to business continuity and crisis management for IT security matters, including preparation, testing, communication, post-incident reviews, and management reporting. Awareness, training, and collaboration: Promote security awareness and training in coordination with HR and management, and ensure effective collaboration across IT, business stakeholders, governance bodies, and external partners. Vendor management and budget responsibility: Support IT partner and third-party security management, contribute to vendor security assessments, and develop, monitor, and report on the central IT security budget.

Main Responsibilities Project Management Plan and manage clinical studies within the framework of scientific and legal guidelines Manage the project portfolio of the assigned clients, coordinating all projects and activities of the assigned clients in order to assist them in achieving their strategic goals Support the clinical operations team to achieve strategic goals and improve internal processes Main contact person for budget development and budget tracking Provide training about budget development and tracking to the team members as required Prepare and coordinate and if required, conduct site initiation visits, monitoring visits and site close-out visits Coordinate the development of Clinical Investigation Plans, Case Report Forms and provide operational expertise as required  Coordinate and develop essential documents for the execution of clinical studies  Validation and control of quality of clinical data Compile and archive study documents  Periodically review study budgets  Provide status information on study data to AO ITC management and clients as required Maintain contact with Principal Investigators and Study Nurses  Evaluate clinical data in collaboration with the Biostatistician, the Medical Advisor and the Medical Writer  Generate budgets for studies and present them for approval to the clients  Define resource allocation for projects and inform other groups on resources required   Contractual negotiations with the study sites   In General Main contact person for clients  Represent AO ITC in Research Commissions  Planning and coordination of the annual research budget  Portfolio management, supervision and overview of dediacted research activities at AO ITC   Quality System The employee performs all tasks in alignment with the requirements of the ISO 9001 quality management standard and actively contributes to maintaining and improving the quality system. The employee undertakes additional responsibilities and duties as assigned by the line manager to support operational and organizational needs related to the Quality Management System.