Jobs

Employment type / Anstellungsverhältnis:  Temporary Workload percentage / Pensum:  100% Location / Standort:   Davos Platz, CH Experience level / gewünschtes Erfahrungsniveau:  Students / Interns Application language / Bewerbungssprache:  English or German Short Description   Fracture-related infection (FRI) remains one of the most challenging complications in orthopaedic trauma, frequently resulting in bone destruction, implant failure, and prolonged treatment. Recent evidence suggests that early infection-induced bone loss is primarily driven by neutrophil-mediated inflammation and proteolytic degradation, alongside classical osteoclast-driven pathways.  This project (DONUT – Development of advanced Osteolysis Model drive by NeUTrophils) aims to further our knowledge on this topic by developing a novel human-relevant 3D in vitro model that integrates: Spatially organized bone constructs generated using Sound-Induced Morphogenesis Integration of immune cell populations including neutrophils Controlled introduction of Staphylococcus aureus Advanced molecular and imaging-based readouts The project will enable mechanistic insights into infection-induced osteolysis and provide a platform for testing new therapeutic strategies.   Start of work: Position will remain open until role is filled, preferred start by October 2026. Duration: 4 years Main Responsibilities   Develop and optimise 3D biofabricated bone model with immune cells Establish infection models with Staphylococcus aureus Introduce and study neutrophil-driven inflammatory processes Apply advanced analytical techniques (e.g. imaging, transcriptomics, cytokine profiling) Analyse and interpret experimental data Contribute to scientific publications and presentations

Employment type / Anstellungsverhältnis:  Temporary Workload percentage / Pensum:  100% Location / Standort:   Davos Platz, CH Experience level / gewünschtes Erfahrungsniveau:  Students / Interns Application language / Bewerbungssprache:  English or German Short Description This PhD position is part of the PREPARE project (Programmable Release of Prophylactic Antibacterial & Response Enhancing agents), a collaborative initiative between the Infection Biology and Biomedical Materials Focus Areas at the AO Research Institute Davos and CK CARE (Prof. Pierre Yves Mantel).  The Ph.D. student will be formally affiliated with the University of Fribourg and will be co-supervised by Prof. Michael Walch, Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine at the University of Fribourg. Fracture-related infection (FRI) remains a major clinical challenge despite current prophylactic strategies. Increasing evidence shows that early infection establishment is driven by rapid formation of Staphylococcus aureus microaggregates and transient impairment of neutrophil antibacterial function following trauma. The PREPARE project aims to address this problem by: Defining the earliest events enabling bacterial survival in the surgical field (aggregate formation, fibrin encapsulation, antibiotic tolerance) Identifying small-molecule immunomodulators that enhance neutrophil antibacterial activity Contributing to the development of next-generation responsive biomaterials for localized infection prevention    Start of work: Position will remain open until role is filled, preferred start by October 2026.  Duration: 4 years  Main Responsibilities   Establish and optimise advanced 3D in vitro infection models (e.g. staphylococcal abscess communities) Investigate early events in infection establishment, including bacterial aggregation, fibrin encapsulation, and antibiotic tolerance Characterise neutrophil–bacteria interactions, including phagocytosis, ROS production, and bacterial killing Identify and evaluate immunomodulatory compounds that enhance neutrophil function Perform cell culture and co-culture experiments using primary human neutrophils and bacterial pathogens Apply advanced techniques including confocal microscopy, flow cytometry, and molecular assays Analyse and interpret complex experimental datasets Contribute to interdisciplinary collaboration with biomaterials researchers within the PREPARE project

Short Description   The IT Vendor Managemnet Specialist is responsible for the strategic, operational, and financial management of all external IT partners, service providers, and technology vendors of the AO IT organization. The position ensures that all vendor delivered services meet the AO’s expectations in quality, security, cost efficiency, compliance, and performance. The role collaborates closely with Procurement, Security, IT Architecture, Infrastructure, IT Business Applications, Service Desk, and key business stakeholders to guarantee end to end service continuity and a professional vendor ecosystem. Main Responsibilities   Vendor & Third-Party Management (60% of the role):   Develop, implement, and continuously improve the AO’s vendor management framework, including policies, governance, and lifecycle management Drive vendor consolidation Strongly support changing vendors delivery method from a staff augmentation to a managed work approach Lead the full lifecycle: sourcing, evaluation, onboarding, contracting, performance management, productivity, renewal, and offboarding Ensure compliance with AO information security and regulatory requirements, including periodic vendor audits and assessments   Contract, Commercial & Financial Management Lead contract negotiations in cooperation with IT procurement to secure cost-effective and high-quality services Manage vendor-related budgeting, financial forecasting, spend tracking, and cost optimization Ensure alignment of all contracts with AO legal, procurement, and compliance requirements   SLA, KPI & Performance Management Define service levels, KPIs, OLAs, and performance measures for all external providers Conduct structured performance reviews with vendors, including escalations and corrective action plans Ensure transparency of service quality through standardized reporting and dashboards   Risk, Security & Compliance Ensure that all vendors adhere to AO’s Information Security Policy, IAM requirements, data-protection standards, and incident-response expectations Work with the IT Security Manager to manage vendor-related risk assessments, security audits, and continuous improvement measures Maintain a vendor risk register and ensure mitigation actions are implemented   Operations and Management Coordination (20% of role):   Team & Operational Coordination Coordinate administrative and organizational activities within IT, maintain documentation and governance materials, and support planning of meetings, presentations, workshops, and reports.   Management Support Serve as a central coordination point for IT leadership, stakeholders, and partners; track initiative progress, highlight priorities and risks, and prepare briefings to support decision-making.   Partner & Stakeholder Management Assist with partner coordination, meeting documentation, and action tracking while ensuring clear communication and strong relationships with vendors and service providers.   Operational Improvement Identify workflow inefficiencies, propose improvements, support digital tools and automation, and help monitor costs and performance to drive operational excellence.

Employment type / Anstellungsverhältnis:  Permanent Workload percentage / Pensum:  100% Location / Standort:   Davos Platz, CH Experience level / gewünschtes Erfahrungsniveau:  Experienced professional Application language / Bewerbungssprache:  English or German Short Description   As Project Manager - Medical Simulation, you will bridge the gap between practical execution and strategic vision, ensuring our simulation-based education programs maintain the highest standards while evolving to meet future needs. You will be instrumental in bringing cutting-edge simulation technologies to healthcare professionals around the world. Main Responsibilities   Operational Management Execute the setup, operation, and maintenance of simulation equipment for international training events Manage biological specimen handling and logistics in compliance with international regulations Coordinate logistical aspects of simulation-based training events in Davos and support global locations Oversee import/export requirements for specialized training materials Maintain and organize simulation equipment, tools, and supplies inventory   Project Implementation Implement simulation-based training projects from planning to delivery Track project milestones, timelines, and deliverables Resolve operational challenges during project execution Document processes and outcomes to support continuous improvement Coordinate cross-functional team activities to achieve project goals   Technology & Innovation Support the evaluation of novel, simulation-based learning experiences  Contribute to the development and go2market of digital simulation tools Assist in managing relationships with technology and service partners Provide input on scalability opportunities for simulation programs Help implement emerging technologies in simulation education

Short Description   The Head of Medical Scientific Affairs provides strategic and scientific leadership for AO's clinical evidence generation ecosystem and ensures that clinical research investments translate into meaningful improvements in patient care.  He/she serves as a trusted scientific advisor to AO leadership, governance committees, and clinical divisions and represents AO ITC in internal and external scientific initiatives, partnerships, and expert forums.  The role is accountable for developing a high-impact portfolio of clinical studies across Trauma, CMF, Spine,TC, Veterinary, and related orthopedic disciplines, ensuring optimal allocation of resources, scientific excellence, and supporting effective translation of evidence into clinical practice.  The position serves as a key interface between surgeons, researchers, clinical operations, governance bodies, industry partners, and educational stakeholders to maximize the generation, dissemination, and adoption of evidence-based innovations within the AO ecosystem.     Main Responsibilities   Lead the Medical Scientific Affairs team  Provide scientific, strategic and operational leadership to the Medical Scientific Affairs team with two direct reports, fostering a high-performing, collaborative, and service-oriented culture.  Define team objectives, priorities, and performance expectations aligned with the organization's strategy and portfolio needs.  Recruit, develop, coach, and evaluate team members to support professional growth, ensuring the appropriate scientific, clinical, and operational competencies are in place.  Close collaboration with Clinical Operations in the resource planning and allocation across studies, programs, and stakeholder requests to meet organizational objectives.  Build effective collaboration between surgeons, governance bodies, Clinical Operations, NCR, AO Education Institute, AO Research Institute, educators, and external partners to advance the Clinical Research activities in the AO.  Drive continuous improvement of Medical Scientific Affairs processes, standards, and capabilities to enhance quality, efficiency, and impact and establish a culture of scientific excellence, integrity, compliance, and evidence-based decision-making across all Medical Scientific Affairs activities.  Lead the Clinical Science Advisory Commission (CSAC).  Lead the AO ITC Clinical Research Fellowship Program.  Support the AO PEER program.    Clinical Study Design & Scientific Support  Develop clinical study protocols addressing important knowledge gaps and clinical needs in close collaboration with surgeons, industry partners, governance bodies and Network Clinical Research and Clinical Operations.  Review and provide medical-scientific assessment of adverse events and safety-related findings throughout study conduct.  Provide expert advice on medical and scientific questions arising during study execution and support preparation of scientific publications, clinical reports, congress abstracts, and other dissemination activities.  Close collaborate with Clinical Operations in study planning, implementation, and monitoring activities.  Support interpretation of results in close collaboration with surgeons, investigators, governance bodies, and Clinical Operations.  Drive excellence in scientific publication strategies, congress presentations, and dissemination activities.    Clinical Research Portfolio Strategy  Lead scientific discussions regarding future evidence needs.  Develop and maintain a strategic clinical research portfolio in collaboration with the Research Commissions and internal stakeholders which is aligned with AO's mission and priorities.  Establish and continuously refine portfolio prioritization frameworks balancing available research funding, knowledge gaps, patient impact, scientific significance, feasibility, cost-effectiveness and translational potential and risk-benefit considerations in collaboration with the Research Commissions and internal stakeholders.  Monitor portfolio performance with regards to strategic objectives and adapt research priorities based on emerging evidence, and clinical needs.  Provide scientific leadership across the full research lifecycle, ensuring methodological rigor, clinical relevance, regulatory compliance, and ethical conduct.  Collaborate with Clinical Operations in establishing a grant acquisition strategy and strengthen industry partnerships and drive grant acquisition.  Support Knowledge Translation activities to ensure clinical evidence generated by AO is effectively translated into education, clinical guidelines, decision support tools, and clinical practice.  Collaborate closely with Clinical Operations, NCR, AO Education, AO Clinical Divisions, community development and governance bodies to facilitate adoption of new evidence.  Lead implementation of health economic and outcomes research initiatives.